Publications
"Nothing in science has any value to society if it is not communicated" - Anne Roe
We believe it is our duty as scientists to openly communicate our findings and tools to the scientific community and the broader public. The Cai Lab is committed to accessible and transparent science.
Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy
Feng Y, Diego KS, Dong Z, Wick ZC, Page-Harley L, Page-Harley V, Schnipper J, Lamsifer SI, Pennington ZT, Vetere LM, Philipsberg PA, Soler I, Jurkowski A, Rosado CJ, Khan NN, Cai DJ, Shuman T. (2024). bioRxiv
A double hit of social and economic stress in mice precipitates changes in decision-making strategies
Durand-de Cuttoli R, Martínez-Rivera FJ, Li L, Minier-Toribio A, Dong Z, Cai DJ, Russo SJ, Nestler EJ, Sweis BM. (2023). Biological Psychiatry
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D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning
Zachry JE, Kutlu MG, Yoon HJ, Leonard MZ, Chevy M, Patel DD, Gaidici A, Kondev V, Thibeault KC, Bethi R, Tat J, Melguin PR, Isiktas AU, Joffe ME, Cai DJ, Conn PJ, Grueter BA & Calipari ES. (2023). Neuron
Current status and future strategies for advancing functional circuit mapping in vivo
Berndt A, Cai DJ, Cohen A, Juarez B, Iglesias J, Xiong H, Qin Z, Tian L & Slesinger P. (2023). Journal of Neuroscience
Chronotate: An open-source tool for manual timestamping and quantification of animal behavior
Philipsberg PA, Christenson Wick Z, Diego KS, Vaughan N, Galas A, Jurkowski A, Feng Y, Vetere LM, Chen L, Soler I, Cai DJ & Shuman T. (2023). Neuroscience Letters
Aversive experience drives offline ensemble reactivation to link memories across days
Zaki Y, Pennington ZT, Morales-Rodriguez D, Francisco TR, LaBanca AR, Dong Z, Lamsifer S, Carrillo Segura S, Chen HT, Christenson Wick Z, Silva AJ, van der Meer M, Shuman T, Fenton A, Rajan K & Cai DJ. (2023) bioRxiv
Drift of neural ensembles driven by slow fluctuations of intrinsic excitability
Delamare G, Zaki Y, Cai DJ, Clopath C. (2023) eLife
Progressive excitability changes in the medial entorhinal cortex in the 3xTg mouse model of Alzheimer's disease pathology
Chen L, Christenson Wick Z, Vetere LM, Vaughan N, Jurkowski A, Galas A, Diego KS, Philipsberg P, Soler I, Feng Y, Cai DJ & Shuman T (2023) Journal of Neuroscience
Dissociable contributions of the amygdala and ventral hippocampus to stress-induced changes in defensive behavior
Pennington ZT, LaBanca AR, Sompolpong P, Christenson Wick Z, Feng Y, Dong Z, Francisco T, Chen L, Fulton SL, Maze I, Shuman T, Cai DJ (2023) bioRxiv
Ensemble-specific deficit in neuronal intrinsic excitability in aged mice
Chen L, Francisco TR, Baggetta AM, Zaki Y, Ramirez S, Clem RL, Shuman T, Cai DJ (2023) Neurobiology of Aging
Ensemble remodeling supports memory-updating
Mau W, Baggetta AM, Dong Z, Sweis BM , Morales-Rodriguez D , Pennington ZT, Francisco TR , Freedman DJ , Baxter MG, Shuman T, Cai DJ (2022) bioRxiv
Minian: An open-source miniscope analysis pipeline
It all begins with an idea.
Dong Z, Mau W, Feng Y, Pennington ZT, Chen L, Zaki Y, Rajan K, Shuman T, Aharoni D, Cai DJ (2022) eLife
CCR5 closes the temporal window for memory linking
It all begins with an idea.
Shen Y, Zhou M, Cai DJ, Filho DA, Fernandes G, Cai Y, Kim N, Necula D, Zhou C, Liu A, Kang X, Kamata M, Lavi A, Huang S, Silva T, Heo WD, Silva AJ (2022) Nature
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A distinct signaling pathway in parvalbumin-positive interneurons controls flexible memory updating
Cai DJ, Shuman T (2022) Neuropsychopharmacology
Dynamic and heterogeneous neural ensembles contribute to a memory engram
It all begins with an idea.
Sweis BM, Mau W, Rabinowitz S, Cai DJ (2021) Current Opinion in Neurobiology
Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior
It all begins with an idea.
Blaze J, Navickas A, Phillips HL, Heissel S, Plaza-Jennings A, Miglani S, Asgharian H, Foo M, Katanski CD, Watkins CP, Pennington ZT, Javidfar B, Espeso-Gil S, Rostandy B, Alwaseem H, Hahn CG, Molina H, Cai DJ, Pan T, Yao WD, Goodarzi H, Haghighi F, Akbarian S (2021) Nature Communications
ezTrack - A step-by-step guide to behavior tracking
Pennington ZT, Diego KS, Francisco TR, LaBanca AR, Lamsifer SI, Liobimova O, Shuman T, Cai DJ (2021) Current Protocols
Propranolol inhibits reactivation of fear memory
Pennington ZT, Cai DJ (2021) Biological Psychiatry
Breakdown of spatial coding and interneuron synchronization in epileptic mice
Shuman T, Aharoni D, Cai DJ, Lee CR, Chavlis S, Page-Harley L, Vetere LM, Feng Y, Yang CY, Mollinedo-Gajate I, Chen L, Pennington ZT, Taxidis J, Flores SE, Cheng K, Javaherian M, Kaba CC, Rao N, La-Vu M, Pandi I, Shtrahman M, Bakurin KI, Masmanidis S, Kakh MS, Poirazi P, Silva AJ, Golshani P (2020) Nature
The lab on lockdown: Thinking back and looking ahead
Poe GR, Cai DJ (2020) Nature Reviews Neuroscience